Distinct Regulation of Cytoplasmic Calcium Signals and Cell Death Pathways by the Plasma Membrane Calcium ATPase Isoforms 1 and 4 in MDA - MB - 231 Breast Cancer Cells

نویسندگان

  • Merril C Curry
  • Nicole A Luk
  • Sarah J Roberts-Thomson
  • Gregory R Monteith
چکیده

CAPSULE Background: The roles of different PMCA isoforms are not fully understood particularly in cell death. Results: PMCA4 and PMCA1 silencing has differential effects on Ca signaling and caspasedependent and independent cell death in MDAMB-231 cells. Conclusion: PMCA isoforms have distinct roles in the control of cell death pathways. Significance: Inhibition of PMCA4 may increase the effectiveness of some cancer therapies.

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تاریخ انتشار 2015